Miriam Blaylock (Catherine Deneuve) collects Renaissance art, ancient Egyptian pendants, lovers, souls. Alive and fashionably chic in Manhattan, Miriam is an ageless vampire; blessed with beauty, cursed with bloodlust. She lives through the ages with fellow fiend and refined husband, John, played by rock legend David Bowie. In love, in life, in longing they are inseparable. But when John abruptly begins to age and turns to a geriatrics researcher for help, Miriam soon eyes the woman (Academy Award winner Susan Sarandon) as a replacement for John.
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