Hardworking and ambitious, Tiana dreams of one day opening the finest restaurant in New Orleans. Her dream takes a slight detour when she meets Prince Naveen, who has been turned into an amphibian by evil Dr. Facilier.

Mistaking her for a princess and hoping to break the spell, Naveen plants a kiss on poor Tiana -- thereby turning her into a frog as well. The pair hop along on an adventure through the bayous to seek the help of a powerful voodoo priestess.