Reeling from a devastating loss, Tana (Lily Gladstone) is pulled back into the world by an unexpected invitation to her cousin's wedding. She packs up her late grandmother's Cadillac and hits the open road, driving from her home in Minnesota to South Dakota. After reconnecting with her Oglala Lakota family, Tana sets off to retrace a surreal journey that her grandmother took decades ago, searching for the spot captured in an old family photograph. As she travels, Tana finds connection in the stories of everyday people who've settled down far off the main roads including Isaac (Raymond Lee), who provides a pivotal clue to understanding the lost location that could cultivate closure.